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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SLC6A4
All Species:
16.36
Human Site:
S52
Identified Species:
32.73
UniProt:
P31645
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P31645
NP_001036.1
630
70325
S52
N
G
Y
S
A
V
P
S
P
G
A
G
D
D
T
Chimpanzee
Pan troglodytes
XP_001135066
630
70262
S52
N
G
Y
S
A
V
P
S
P
G
A
G
D
D
T
Rhesus Macaque
Macaca mulatta
Q9MYX0
630
70239
S52
N
G
Y
S
A
V
P
S
P
G
A
G
D
D
T
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
Q60857
630
70129
S52
N
G
Y
S
A
V
P
S
T
S
A
G
D
E
A
Rat
Rattus norvegicus
P31652
630
70153
S52
N
G
Y
S
A
V
P
S
T
S
A
G
D
E
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508462
865
94609
V282
G
R
K
A
V
E
L
V
L
V
K
E
Q
N
G
Chicken
Gallus gallus
NP_998737
670
74409
A92
D
A
Q
C
T
A
P
A
A
T
T
T
T
T
T
Frog
Xenopus laevis
A7Y2W8
633
71004
F62
N
G
G
G
A
F
M
F
P
Y
F
I
M
L
I
Zebra Danio
Brachydanio rerio
NP_001035061
646
72103
G65
Q
S
P
K
E
G
A
G
T
G
T
D
R
V
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P51905
622
69307
P47
D
D
G
D
H
T
T
P
A
K
V
T
D
P
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q03614
615
69247
L50
W
S
G
K
L
D
F
L
L
S
V
V
G
F
A
Sea Urchin
Strong. purpuratus
XP_001204030
641
70931
E61
E
A
L
S
Q
R
A
E
N
G
Y
R
G
L
N
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
98.5
N.A.
N.A.
92.8
91.7
N.A.
38.1
77.6
42.1
68.5
N.A.
50.4
N.A.
43.6
49.4
Protein Similarity:
100
99.5
99.5
N.A.
N.A.
95.5
94.9
N.A.
52.9
85.2
60.8
80.6
N.A.
66.9
N.A.
63.3
66.6
P-Site Identity:
100
100
100
N.A.
N.A.
73.3
73.3
N.A.
0
13.3
26.6
6.6
N.A.
6.6
N.A.
0
13.3
P-Site Similarity:
100
100
100
N.A.
N.A.
80
80
N.A.
13.3
26.6
26.6
6.6
N.A.
13.3
N.A.
0
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
17
0
9
50
9
17
9
17
0
42
0
0
0
25
% A
% Cys:
0
0
0
9
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
17
9
0
9
0
9
0
0
0
0
0
9
50
25
0
% D
% Glu:
9
0
0
0
9
9
0
9
0
0
0
9
0
17
0
% E
% Phe:
0
0
0
0
0
9
9
9
0
0
9
0
0
9
0
% F
% Gly:
9
50
25
9
0
9
0
9
0
42
0
42
17
0
9
% G
% His:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
9
0
0
9
% I
% Lys:
0
0
9
17
0
0
0
0
0
9
9
0
0
0
0
% K
% Leu:
0
0
9
0
9
0
9
9
17
0
0
0
0
17
9
% L
% Met:
0
0
0
0
0
0
9
0
0
0
0
0
9
0
0
% M
% Asn:
50
0
0
0
0
0
0
0
9
0
0
0
0
9
17
% N
% Pro:
0
0
9
0
0
0
50
9
34
0
0
0
0
9
0
% P
% Gln:
9
0
9
0
9
0
0
0
0
0
0
0
9
0
0
% Q
% Arg:
0
9
0
0
0
9
0
0
0
0
0
9
9
0
0
% R
% Ser:
0
17
0
50
0
0
0
42
0
25
0
0
0
0
0
% S
% Thr:
0
0
0
0
9
9
9
0
25
9
17
17
9
9
34
% T
% Val:
0
0
0
0
9
42
0
9
0
9
17
9
0
9
0
% V
% Trp:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
42
0
0
0
0
0
0
9
9
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _